Abstract
A facile method for in situ fabrication of three-dimensional gold nanoparticle micropatterns in a cell-resistant polyethylene glycol hydrogel has been developed by combining photochemical synthesis of gold nanoparticles with photolithography technology. The gold nanoparticle micropatterns were further bio-modified with cell integrated polypeptide NcysBRGD based on a gold-thiol bond to improve cell behaviors. Primary cell tests showed that NcysBRGD can enhance cell adhesion very well on the surface of gold nanoparticle micropatterns.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Biocompatible Materials / chemistry
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Cell Adhesion
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Equipment Design
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Gold / chemistry*
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HeLa Cells
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Humans
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Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry*
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Metal Nanoparticles / chemistry*
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Metal Nanoparticles / ultrastructure
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Microtechnology
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Molecular Sequence Data
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Peptides / chemistry*
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Sulfhydryl Compounds / chemistry
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Tissue Array Analysis / instrumentation
Substances
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Biocompatible Materials
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Peptides
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Sulfhydryl Compounds
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Hydrogel, Polyethylene Glycol Dimethacrylate
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Gold