AIF Is "Always In Fashion" for T Cells

Marc O Johnson; Jeffrey C Rathmell

doi:10.1016/j.immuni.2015.12.015

AIF Is "Always In Fashion" for T Cells

Immunity. 2016 Jan 19;44(1):11-13. doi: 10.1016/j.immuni.2015.12.015.

Authors

Marc O Johnson¹, Jeffrey C Rathmell²

Affiliations

¹ Vanderbilt Center for Immunobiology, Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN 37232, USA.
² Vanderbilt Center for Immunobiology, Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN 37232, USA. Electronic address: [email protected].

Abstract

AIF has been known to have both apoptotic and metabolic roles. Green and colleagues show that T cells, but not B cells, rely on AIF to maintain mitochondrial electron transport and that metabolic, rather than apoptotic, pathways mediate this dependence.

Publication types

Comment

MeSH terms

Animals
Apoptosis Inducing Factor / metabolism*
B-Lymphocytes / metabolism*
Mitochondria / physiology*
T-Lymphocytes / metabolism*

Substances

Apoptosis Inducing Factor

Abstract

Publication types

MeSH terms

Substances

Grants and funding