TCR αβ and CD19-depleted haploidentical stem cell transplant with reduced intensity conditioning for Hoyeraal-Hreidarsson syndrome with RTEL1 mutation

Bone Marrow Transplant. 2016 May;51(5):753-4. doi: 10.1038/bmt.2015.352. Epub 2016 Jan 25.

Authors

R Bhattacharyya¹, A M Tan¹, M Y Chan¹, S S Jamuar^{1

2}, R Foo^{3

4}, P Iyer¹

Affiliations

¹ Department of Paediatric Subspecialties, Haematology Oncology Service, KK Women's and Children's Hospital, Singapore, Singapore.
² Paediatric Academic Clinical Programme, Singhealth Duke-NUS Graduate Medical School, Singapore, Singapore.
³ Genome Institute of Singapore, Singapore, Singapore.
⁴ Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore.

PMID: 26808564
DOI: 10.1038/bmt.2015.352

No abstract available

Publication types

Case Reports

MeSH terms

Antigens, CD19 / genetics
Antigens, CD19 / metabolism*
DNA Helicases / genetics*
Dyskeratosis Congenita / genetics
Dyskeratosis Congenita / therapy*
Fetal Growth Retardation / genetics
Fetal Growth Retardation / therapy*
Humans
Infant
Intellectual Disability / genetics
Intellectual Disability / therapy*
Male
Microcephaly / genetics
Microcephaly / therapy*
Mutation
Prognosis
Receptors, Antigen, T-Cell, alpha-beta / genetics
Receptors, Antigen, T-Cell, alpha-beta / metabolism*
Stem Cell Transplantation*
Transplantation Conditioning / methods

Substances

Antigens, CD19
CD19 molecule, human
Receptors, Antigen, T-Cell, alpha-beta
RTEL1 protein, human
DNA Helicases

Supplementary concepts

Hoyeraal Hreidarsson syndrome