Does the preference of peripheral versus central venous access in peripheral blood stem cell collection/yield change stem cell kinetics in autologous stem cell transplantation?

Transfus Apher Sci. 2016 Feb;54(1):76-9. doi: 10.1016/j.transci.2016.01.017. Epub 2016 Jan 11.

Abstract

Central venous access is often used during apheresis procedure in stem cell collection. The aim of the present study was to evaluate whether central or peripheral venous access has an effect on stem cell yield and the kinetics of the procedure and the product in patients undergoing ASCT after high dose therapy. A total of 327 patients were retrospectively reviewed. The use of peripheral venous access for stem cell yield was significantly more frequent in males compared to females (p = 0.005). Total volume of the product was significantly lower in central venous access group (p = 0.046). As being a less invasive procedure, peripheral venous access can be used for stem cell yield in eligible selected patients.

Keywords: Apheresis; Autologous stem cell transplantation; Mobilization.

Publication types

  • Comparative Study

MeSH terms

  • Blood Specimen Collection / methods*
  • Choice Behavior*
  • Demography
  • Female
  • Humans
  • Kinetics
  • Male
  • Middle Aged
  • Peripheral Blood Stem Cell Transplantation*
  • Peripheral Blood Stem Cells / cytology*
  • Transplantation, Autologous