Double robust estimator of average causal treatment effect for censored medical cost data

Stat Med. 2016 Aug 15;35(18):3101-16. doi: 10.1002/sim.6876. Epub 2016 Jan 27.

Abstract

In observational studies, estimation of average causal treatment effect on a patient's response should adjust for confounders that are associated with both treatment exposure and response. In addition, the response, such as medical cost, may have incomplete follow-up. In this article, a double robust estimator is proposed for average causal treatment effect for right censored medical cost data. The estimator is double robust in the sense that it remains consistent when either the model for the treatment assignment or the regression model for the response is correctly specified. Double robust estimators increase the likelihood the results will represent a valid inference. Asymptotic normality is obtained for the proposed estimator, and an estimator for the asymptotic variance is also derived. Simulation studies show good finite sample performance of the proposed estimator and a real data analysis using the proposed method is provided as illustration. Copyright © 2016 John Wiley & Sons, Ltd.

Keywords: average causal treatment effect; censored data; double robust estimator; inverse probability weighted; lifetime medical cost data.

MeSH terms

  • Computer Simulation
  • Health Care Costs*
  • Humans
  • Models, Statistical*
  • Probability