Hyaluronan in adipose tissue: Beyond dermal filler and therapeutic carrier

Sci Transl Med. 2016 Jan 27;8(323):323ps4. doi: 10.1126/scitranslmed.aad6793. Epub 2016 Jan 27.

Abstract

Adipose hyaluronan is increasingly recognized as an active player in adipose tissue fibrosis and metabolic dysfunction. However, this role poses as many challenges as opportunities for therapeutic targeting of adipose tissue dysfunction during nutrient oversupply.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adipokines / metabolism
  • Adipose Tissue / chemistry*
  • Adipose Tissue / physiopathology*
  • Adiposity
  • Animals
  • Collagen / chemistry
  • Dermal Fillers / chemistry
  • Extracellular Matrix / metabolism
  • Fibrosis
  • Humans
  • Hyaluronic Acid / chemistry*
  • Hyaluronoglucosaminidase / metabolism
  • Hypoxia
  • Immune System
  • Neovascularization, Pathologic
  • Obesity / metabolism
  • Obesity / physiopathology
  • Polysaccharides / chemistry
  • Proteoglycans / chemistry

Substances

  • Adipokines
  • Dermal Fillers
  • Polysaccharides
  • Proteoglycans
  • Hyaluronic Acid
  • Collagen
  • Hyaluronoglucosaminidase