Abstract
Sempervirine and analogues were synthesized using a route featuring Sonogashira and Larock Pd-catalyzed reactions. Structure-activity relationships were investigated using three human cancer cell lines. 10-Fluorosempervirine is the most potently cytotoxic member of the family yet described.
MeSH terms
-
Antineoplastic Agents / chemical synthesis*
-
Antineoplastic Agents / chemistry
-
Antineoplastic Agents / pharmacology
-
Catalysis
-
Cell Line, Tumor
-
Drug Screening Assays, Antitumor
-
Humans
-
Molecular Structure
-
Palladium / chemistry*
-
Secologanin Tryptamine Alkaloids / chemical synthesis*
-
Secologanin Tryptamine Alkaloids / chemistry
-
Secologanin Tryptamine Alkaloids / pharmacology*
-
Structure-Activity Relationship
Substances
-
10-fluorosempervirine
-
Antineoplastic Agents
-
Secologanin Tryptamine Alkaloids
-
Palladium
-
sempervirine