Enzootic Arbovirus Surveillance in Forest Habitat and Phylogenetic Characterization of Novel Isolates of Gamboa Virus in Panama

Am J Trop Med Hyg. 2016 Apr;94(4):786-93. doi: 10.4269/ajtmh.15-0445. Epub 2016 Feb 1.

Abstract

Landscape changes occurring in Panama, a country whose geographic location and climate have historically supported arbovirus transmission, prompted the hypothesis that arbovirus prevalence increases with degradation of tropical forest habitats. Investigations at four variably degraded sites revealed a diverse array of potential mosquito vectors, several of which are known vectors of arbovirus pathogens. Overall, 675 pools consisting of 25,787 mosquitoes and representing 29 species from nine genera (collected at ground and canopy height across all habitats) were screened for cytopathic viruses on Vero cells. We detected four isolates of Gamboa virus (family:Bunyaviridae; genus:Orthobunyavirus) from pools of Aedeomyia squamipennis captured at canopy level in November 2012. Phylogenetic characterization of complete genome sequences shows the new isolates to be closely related to each other with strong evidence of reassortment among the M segment of Panamanian Gamboa isolates and several other viruses of this group. At the site yielding viruses, Soberanía National Park in central Panama, 18 mosquito species were identified, and the predominant taxa included A. squamipennis,Coquillettidia nigricans, and Mansonia titillans.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arboviruses / genetics
  • Arboviruses / isolation & purification
  • Arboviruses / physiology*
  • Base Sequence
  • Culicidae / virology
  • Ecosystem*
  • Forests*
  • Genome, Viral / genetics
  • Insect Vectors / virology
  • Molecular Sequence Data
  • Orthobunyavirus / genetics
  • Orthobunyavirus / isolation & purification
  • Orthobunyavirus / physiology*
  • Panama
  • Phylogeny
  • Population Surveillance
  • Sequence Analysis, DNA