ApoA-II HDL Catabolism and Its Relationships With the Kinetics of ApoA-I HDL and of VLDL1, in Abdominal Obesity

Bruno Vergès; Martin Adiels; Jan Boren; Peter Hugh Barrett; Gerald F Watts; Dick Chan; Laurence Duvillard; Sanni Söderlund; Niina Matikainen; Juhani Kahri; Nina Lundbom; Jesper Lundbom; Antti Hakkarainen; Serge Aho; Isabelle Simoneau-Robin; Marja-Riitta Taskinen

doi:10.1210/jc.2015-3740

ApoA-II HDL Catabolism and Its Relationships With the Kinetics of ApoA-I HDL and of VLDL1, in Abdominal Obesity

J Clin Endocrinol Metab. 2016 Apr;101(4):1398-406. doi: 10.1210/jc.2015-3740. Epub 2016 Feb 2.

Authors

Bruno Vergès¹, Martin Adiels¹, Jan Boren¹, Peter Hugh Barrett¹, Gerald F Watts¹, Dick Chan¹, Laurence Duvillard¹, Sanni Söderlund¹, Niina Matikainen¹, Juhani Kahri¹, Nina Lundbom¹, Jesper Lundbom¹, Antti Hakkarainen¹, Serge Aho¹, Isabelle Simoneau-Robin¹, Marja-Riitta Taskinen¹

Affiliation

¹ Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.

PMID: 26835543
DOI: 10.1210/jc.2015-3740

Abstract

We study the associations between apoA-II fractional catabolic rate (FCR) and the kinetics of VLDL subspecies and apoA-I and show that, in abdominally obese individuals, apoA-II FCR is positively and independently associated with both apoA-I FCR and VLDL1-TG indirect FCR.

Publication types

Multicenter Study

MeSH terms

Adult
Aged
Apolipoprotein A-II / metabolism*
Female
Humans
Insulin Resistance
Kinetics
Lipoproteins, HDL / metabolism*
Lipoproteins, VLDL / metabolism*
Male
Metabolic Syndrome / etiology*
Metabolic Syndrome / metabolism*
Metabolic Syndrome / pathology
Middle Aged
Obesity, Abdominal / complications*

Substances

Apolipoprotein A-II
Lipoproteins, HDL
Lipoproteins, VLDL