A patient with complex multiple genomic ALK alterations

Thorax. 2016 Apr;71(4):383-5. doi: 10.1136/thoraxjnl-2015-207950. Epub 2016 Feb 2.

Authors

Xin Liu¹, Shawn J Rice¹, Carlos A Jamis-Dow², Catherine Abendroth³, Siraj Ali⁴, Salah Almokadem¹, Chandra P Belani¹

Affiliations

¹ Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, Pennsylvania, USA.
² Department of Radiology, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.
³ Department of Pathology, Penn State College of Medicine, Hershey, Pennsylvania, USA.
⁴ Foundation Medicine, Cambridge, Massachusetts, USA.

PMID: 26839360
DOI: 10.1136/thoraxjnl-2015-207950

No abstract available

Keywords: Lung Cancer; Non-Small Cell Lung Cancer.

Publication types

Case Reports

MeSH terms

Adenocarcinoma / diagnostic imaging
Adenocarcinoma / drug therapy
Adenocarcinoma / genetics*
Adenocarcinoma / secondary
Aged
Anaplastic Lymphoma Kinase
Brain Neoplasms / diagnostic imaging
Brain Neoplasms / drug therapy
Brain Neoplasms / genetics*
Brain Neoplasms / secondary
Cell Cycle Proteins / genetics
Codon
Crizotinib
DNA-Binding Proteins / genetics
Female
Genomics
Histone-Lysine N-Methyltransferase / genetics
Humans
Lung Neoplasms / diagnostic imaging
Lung Neoplasms / drug therapy
Lung Neoplasms / genetics*
Lung Neoplasms / pathology
MAP Kinase Kinase 4 / genetics
Microtubule-Associated Proteins / genetics
Nuclear Proteins / genetics
Polymorphism, Single Nucleotide*
Protein Kinase Inhibitors / therapeutic use
Pyrazoles / therapeutic use
Pyridines / therapeutic use
Radiography
Receptor Protein-Tyrosine Kinases / genetics*
Ribonucleoproteins / genetics
Serine Endopeptidases / genetics
Splicing Factor U2AF
Transcription Factors / genetics
Translocation, Genetic / genetics
Treatment Outcome

Substances

ARID1A protein, human
BRD4 protein, human
Cell Cycle Proteins
Codon
DNA-Binding Proteins
Microtubule-Associated Proteins
Nuclear Proteins
Protein Kinase Inhibitors
Pyrazoles
Pyridines
Ribonucleoproteins
Splicing Factor U2AF
TP53TG1 protein, human
Transcription Factors
U2AF1 protein, human
Crizotinib
Histone-Lysine N-Methyltransferase
SETD2 protein, human
ALK protein, human
Anaplastic Lymphoma Kinase
Receptor Protein-Tyrosine Kinases
MAP Kinase Kinase 4
MAP2K4 protein, human
EML4 protein, human
Serine Endopeptidases