Concise Review: Cell Therapies for Stroke and Traumatic Brain Injury: Targeting Microglia

Stem Cells. 2016 Mar;34(3):537-42. doi: 10.1002/stem.2253. Epub 2016 Feb 22.

Abstract

We present a model hypothesis of how several types of cell therapies may target microglia as one of the principal cell types contributing to the inflammatory response after brain injury and discuss how imaging of brain inflammation could potentially be applied to develop biomarkers in patients with stroke and TBI enrolled into stem cell clinical trials.

Keywords: Brain injuries; Microglia; Stem cells; Stroke.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Biomarkers
  • Brain Injuries, Traumatic / pathology
  • Brain Injuries, Traumatic / therapy*
  • Cell- and Tissue-Based Therapy / methods*
  • Humans
  • Inflammation / genetics
  • Inflammation / pathology
  • Microglia / metabolism
  • Microglia / pathology
  • Microglia / transplantation
  • Stem Cell Transplantation*
  • Stroke / pathology
  • Stroke / therapy*

Substances

  • Biomarkers