Characterization of Streptococcus pyogenes isolates responsible for adult meningitis in France from 2003 to 2013

Diagn Microbiol Infect Dis. 2016 Apr;84(4):350-2. doi: 10.1016/j.diagmicrobio.2015.12.006. Epub 2015 Dec 17.

Abstract

Sixty-three cases of Streptococcus pyogenes meningitis in adults were studied. Three predominant emm types were associated with meningitis: emm1 (44%), emm3 (11%), and emm6 (11%). Streptococcal toxic shock syndrome and mortality rates were 40% and 38%, respectively.

Keywords: Group A Streptococcus; Meningitis; Multilocus sequence typing; Streptococcus pyogenes; emm cluster; emm type.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, Bacterial / genetics
  • Bacterial Outer Membrane Proteins / genetics
  • Carrier Proteins / genetics
  • Cluster Analysis
  • Female
  • France / epidemiology
  • Humans
  • Male
  • Meningitis, Bacterial / complications*
  • Meningitis, Bacterial / epidemiology
  • Meningitis, Bacterial / microbiology*
  • Meningitis, Bacterial / pathology
  • Middle Aged
  • Multilocus Sequence Typing
  • Shock, Septic / epidemiology
  • Shock, Septic / mortality*
  • Streptococcal Infections / complications*
  • Streptococcal Infections / epidemiology
  • Streptococcal Infections / microbiology*
  • Streptococcal Infections / pathology
  • Streptococcus pyogenes / classification*
  • Streptococcus pyogenes / isolation & purification*
  • Survival Analysis
  • Young Adult

Substances

  • Antigens, Bacterial
  • Bacterial Outer Membrane Proteins
  • Carrier Proteins
  • streptococcal M protein