Mom Knows Best: Imprinted Control of Hematopoietic Stem Cell Quiescence

Juana Serrano-Lopez; Jose A Cancelas

doi:10.1016/j.stem.2016.01.004

Mom Knows Best: Imprinted Control of Hematopoietic Stem Cell Quiescence

Cell Stem Cell. 2016 Feb 4;18(2):158-60. doi: 10.1016/j.stem.2016.01.004.

Authors

Juana Serrano-Lopez¹, Jose A Cancelas²

Affiliations

¹ Division of Experimental Hematology, Cincinnati Children's Research Foundation, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.
² Division of Experimental Hematology, Cincinnati Children's Research Foundation, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA; Hoxworth Blood Center, University of Cincinnati College of Medicine, 3130 Highland Avenue, Cincinnati, OH 45267, USA. Electronic address: [email protected].

Abstract

The mechanisms by which imprinted loci control activity of hematopoietic stem cells (HSCs) are not known. In this issue of Cell Stem Cell, Qian et al. (2016) demonstrate that non-coding RNAs expressed by the maternal-imprinted locus Dlk1-Gtl2 maintain HSC self-renewal through the inhibition of PI3K-mTOR signaling, mitochondrial biogenesis, and metabolic activity.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Hematopoietic Stem Cells / metabolism*
Humans
Phosphatidylinositol 3-Kinases / metabolism*
Signal Transduction

Substances

Phosphatidylinositol 3-Kinases

Abstract

Publication types

MeSH terms

Substances

Grants and funding