EUCAST technical note on isavuconazole breakpoints for Aspergillus, itraconazole breakpoints for Candida and updates for the antifungal susceptibility testing method documents

M C Arendrup; J Meletiadis; J W Mouton; J Guinea; M Cuenca-Estrella; K Lagrou; S J Howard; Subcommittee on Antifungal Susceptibility Testing (AFST) of the ESCMID European Committee for Antimicrobial Susceptibility Testing (EUCAST)

doi:10.1016/j.cmi.2016.01.017

EUCAST technical note on isavuconazole breakpoints for Aspergillus, itraconazole breakpoints for Candida and updates for the antifungal susceptibility testing method documents

Clin Microbiol Infect. 2016 Jun;22(6):571.e1-4. doi: 10.1016/j.cmi.2016.01.017. Epub 2016 Feb 3.

Authors

M C Arendrup¹, J Meletiadis², J W Mouton³, J Guinea⁴, M Cuenca-Estrella⁵, K Lagrou⁶, S J Howard⁷; Subcommittee on Antifungal Susceptibility Testing (AFST) of the ESCMID European Committee for Antimicrobial Susceptibility Testing (EUCAST)

Collaborators

Subcommittee on Antifungal Susceptibility Testing (AFST) of the ESCMID European Committee for Antimicrobial Susceptibility Testing (EUCAST):
M C Arendrup, J Meletiadis, S J Howard, J Mouton, J Guinea, K Lagrou, S Arikan-Akdagli, F Barchiesi, P Hamal, H Järv, C Lass-Flörl, M Mares, T Matos, K Muehlethaler, T R Rogers, C Torp Andersen, P Verweij

Affiliations

¹ Unit of Mycology, Department of Microbiological Surveillance and Research, Statens Serum Institut, Copenhagen, Denmark. Electronic address: [email protected].
² Clinical Microbiology Laboratory, Attikon University Hospital, University of Athens, Athens, Greece; Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands.
³ Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands; Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, The Netherlands.
⁴ Servicio de Microbiología Clínica y Enfermedades Infecciosas, Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
⁵ Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Spain.
⁶ Department of Microbiology and Immunology, KU Leuven-University of Leuven, Leuven and National Reference Centre for Mycosis, UZ Leuven, Leuven, Belgium.
⁷ NIHR CLAHRC Greater Manchester, Salford Royal NHS Foundation Trust, Salford, Greater Manchester, UK.

PMID: 26851656
DOI: 10.1016/j.cmi.2016.01.017

Abstract

The Subcommittee on Antifungal Susceptibility Testing (AFST) of the ESCMID European Committee for Antimicrobial Susceptibility Testing (EUCAST) has determined breakpoints for isavuconazole and Aspergillus and for itraconazole and Candida spp., released a new document summarizing existing and new minimum inhibitory concentration ranges for quality control strains and revised the method documents for yeast and mould susceptibility testing. This technical note is based on the EUCAST isavuconazole and itraconazole rationale documents, version 1.0 of the routine and extended internal quality control for antifungal susceptibility testing as recommended by EUCAST, and the E.Def 7.3, E.Def 9.2 and E.Def 9.3 method documents (http://www.eucast.org).

Keywords: Antifungal susceptibility testing; QC MIC ranges; breakpoints; isavuconazole; itraconazole.

MeSH terms

Antifungal Agents / pharmacology*
Fungi / drug effects*
Microbial Sensitivity Tests / standards*
Quality Control

Substances

Antifungal Agents