Complete genome sequence of Streptomyces globisporus C-1027, the producer of an enediyne antibiotic lidamycin

J Biotechnol. 2016 Mar 20:222:9-10. doi: 10.1016/j.jbiotec.2016.02.004. Epub 2016 Feb 4.

Abstract

Streptomyces globisporus C-1027 produces a nine-membered enediyne antitumor antibiotic lidamycin. Here we report the complete genome sequence of S. globisporus C-1027, which consists of a 7,608,611 bp linear chromosome, a 167,754 bp linear plasmid SGLP1 and a 7,234 bp circular plasmid pSGL1. The biosynthetic gene cluster for lidamycin was located in the linear plasmid SGLP1. Genome analysis also revealed a number of genes related to biosynthesis of diverse secondary metabolites. The genome sequence of C-1027 will enable us to disclose biosynthetic pathways of these secondary metabolites and discover new natural products with potential applications notably in human health.

Keywords: Genome sequence; Lidamycin; Streptomyces globisporus C-1027.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminoglycosides*
  • Enediynes*
  • Genome, Bacterial / genetics*
  • Streptomyces / genetics*
  • Streptomyces / metabolism

Substances

  • Aminoglycosides
  • Enediynes
  • C 1027