Cross-talk between freezing response and signaling for regulatory transcriptions of MIR475b and its targets by miR475b promoter in Populus suaveolens

Sci Rep. 2016 Feb 8:6:20648. doi: 10.1038/srep20648.

Abstract

MicroRNAs (miRNAs) are small, non-coding RNAs that play important roles in post-transcriptional regulation of their target genes, yet the transcriptional regulation of plant miRNAs by promoter is poorly understood. Here, we firstly clone pri-miR475b cDNA and its native promoter from P. suaveolens, and characterize Psu-MIR475b as class-II gene transcribed by RNA polymerase II. By 5' deletion analysis of Psu-miR475b promoter in a series of promoter-GUS chimeric vectors, we functionally identify three positive regulatory regions and multiple cis-acting elements responsible for Psu-miR475b promoter activity in response to freezing stress and exogenous hormone treatment. Moreover, the Psu-miR475b promoter activity displays a tissue-specific manner, negatively regulated by freezing stress and positively by MeJA, SA or GA treatment. Importantly, we comparatively analyze the time-course transcriptional profiles of Psu-miR475b and its targets in Psu-miR475b over-expression transgenic plants controlled by Psu-miR475b-specific promoter or CaMV 35S constitutive promoter, and explore the regulatory mechanism of Psu-miR475b promoter controlling transcriptional expressions of Psu-MIR475b and its targets in response to freezing stress and exogenous hormone treatment. Our results reveal that Psu-miR475b promoter-mediated transcriptions of Psu-MIR475b and its targets in response to freezing stress may be involved in a cross-talk between freezing response and stress signaling process.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetates / pharmacology
  • Base Sequence
  • Cyclopentanes / pharmacology
  • Freezing*
  • MicroRNAs / genetics
  • MicroRNAs / metabolism*
  • Molecular Sequence Data
  • Oxylipins / pharmacology
  • Plant Growth Regulators / pharmacology
  • Plants, Genetically Modified / genetics
  • Plants, Genetically Modified / metabolism
  • Populus / genetics
  • Populus / metabolism*
  • Promoter Regions, Genetic
  • Regulatory Elements, Transcriptional / genetics
  • Salicylic Acid / pharmacology
  • Signal Transduction / drug effects
  • Signal Transduction / genetics
  • Transcriptome / drug effects

Substances

  • Acetates
  • Cyclopentanes
  • MicroRNAs
  • Oxylipins
  • Plant Growth Regulators
  • methyl jasmonate
  • Salicylic Acid