miR-126 Drives Quiescence and Self-Renewal in Leukemic Stem Cells

Simon Raffel; Andreas Trumpp

doi:10.1016/j.ccell.2016.01.007

miR-126 Drives Quiescence and Self-Renewal in Leukemic Stem Cells

Cancer Cell. 2016 Feb 8;29(2):133-5. doi: 10.1016/j.ccell.2016.01.007.

Authors

Simon Raffel¹, Andreas Trumpp²

Affiliations

¹ Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120 Heidelberg, Germany; Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ), 69120 Heidelberg, Germany.
² Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120 Heidelberg, Germany; Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ), 69120 Heidelberg, Germany. Electronic address: [email protected].

PMID: 26859449
DOI: 10.1016/j.ccell.2016.01.007

Abstract

Leukemic stem cells (LSCs) are resistant to conventional chemotherapy and promote acute myeloid leukemia (AML) progression and recurrence. In this issue of Cancer Cell, Lechman and colleagues (2016) identify the microRNA miR-126 as a regulator of PI3K-AKT-mTOR and CDK3 signaling driving LSC self-renewal and chemotherapy resistance.

Publication types

Comment

MeSH terms

Animals
Hematopoietic Stem Cells / pathology*
Humans
Leukemia, Myeloid, Acute / pathology*
MicroRNAs / physiology*

Substances

MicroRNAs