Neurovascular Stains in Two Girls with Neurofibromatosis 1

Pediatr Dermatol. 2016 Mar-Apr;33(2):e158-9. doi: 10.1111/pde.12793. Epub 2016 Feb 10.

Abstract

We report two girls, ages 9 and 17 years, with a clinical diagnosis of neurofibromatosis 1 (NF-1) who presented with ill-defined, blanchable, erythematous patches on the dorsal feet and ankles. We hypothesized that these patches were a rare cutaneous finding in NF-1 that exist on a clinical and histopathologic spectrum with previously described NF-1 vascular lesions including blue-red macules and skin ulceration due to NF-1 vasculopathy. We suggest that these lesions be called neurovascular stains (NVSs) to unify their clinical and histopathologic features.

MeSH terms

  • Adolescent
  • Blood Vessels / pathology
  • Child
  • Female
  • Humans
  • Neurofibromatosis 1 / pathology*