Abstract
Sorazolons A (1) to E2 (9) were isolated from Sorangium cellulosum strain Soce375. Their molecular structures were elucidated using extensive HRESIMS and NMR analysis. The absolute configuration of sorazolon A (1) was determined by comparison of the experimental CD spectrum with quantum chemical calculated spectra for both enantiomers. Sorazolons D2 (7), E (8), and E2 (9) exhibit a moderate cytotoxic activity against mouse fibroblast cell line L929 with IC50 values between 5.0 μM and 0.09 mM.
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Animals
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Bacillus subtilis / drug effects
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Candida albicans / drug effects
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Carbazoles
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Crystallography, X-Ray
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Escherichia coli / drug effects
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Fibroblasts / drug effects
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Mice
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Microbial Sensitivity Tests
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Micrococcus luteus / drug effects
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Molecular Conformation
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Molecular Structure
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Mucor / drug effects
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Mycobacterium smegmatis / drug effects
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Myxococcales / chemistry*
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Pseudomonas aeruginosa / drug effects
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Staphylococcus aureus / drug effects
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Stereoisomerism
Substances
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Alkaloids
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Carbazoles
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sorazolon A
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sorazolon E
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sorazolon E2