Carbapenem- and Colistin-Resistant Enterobacter cloacae from Delta, Colorado, in 2015

Andrew P Norgan; Jarred M Freese; Patricia M Tuin; Scott A Cunningham; Patricio R Jeraldo; Robin Patel

doi:10.1128/AAC.03055-15

Carbapenem- and Colistin-Resistant Enterobacter cloacae from Delta, Colorado, in 2015

Antimicrob Agents Chemother. 2016 Apr 22;60(5):3141-4. doi: 10.1128/AAC.03055-15. Print 2016 May.

Authors

Andrew P Norgan¹, Jarred M Freese², Patricia M Tuin², Scott A Cunningham³, Patricio R Jeraldo⁴, Robin Patel⁵

Affiliations

¹ Department of Laboratory Medicine and Pathology, Rochester, Minnesota, USA.
² Delta County Memorial Hospital, Delta, Colorado, USA.
³ Division of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA.
⁴ Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA.
⁵ Division of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA [email protected].

Abstract

Resistance to carbapenems in Enterobacteriaceae is a clinical problem of growing significance. Difficulty in treating multidrug-resistant Gram-negative organisms with conventional antibiotics has led to a renewed and increasing use of polymyxin compounds, such as colistin. Here, we report the isolation of carbapenem- and colistin-resistant Enterobacter cloacae from a polymicrobial lower extremity wound in an ambulatory patient. Whole-genome sequencing demonstrated the presence of chromosomal blaIMI-1 and blaAmpC, as well as numerous efflux pump genes.

MeSH terms

Carbapenems / pharmacology*
Colistin / pharmacology*
Colorado
Drug Resistance, Multiple
Enterobacter cloacae / drug effects*
Gram-Negative Bacteria / drug effects*
Microbial Sensitivity Tests

Substances

Carbapenems
Colistin