Prognostic value of three pro-nuclei (3PN) incidence in elective single blastocyst-stage embryo transfer

Int J Clin Exp Med. 2015 Nov 15;8(11):21699-702. eCollection 2015.

Abstract

Objectives: To investigate whether 3PN incidence could lead to a worse pregnancy outcome of elective single blastocyst stage embryo transfer (eSBET).

Methods: This study included 706 eSBET cycles from January 2013 to March 2015. The patients were divided into two groups as follows: group 1 included 286 patients with no 3PN zygotes and group 2 included 420 patients with 3PN zygotes.

Main outcome measure: female age, endometrial thickness, infertility duration, type of infertility, main etiology of infertility, clinical pregnancy and abortion rate.

Results: We observed that there was no significant difference in female age, endometrial thickness, infertility duration and abortion rate between two groups. It's worth noting that the clinical pregnancy rate in 3PN > 0% group was significantly lower than 3PN = 0 group (P = 0.021).

Conclusions: 3PN incidence might make anegative effect on pregnancy outcomes in elective single blastocyst stage embryo transfer.

Keywords: 3PN; pregnancy; single blastocyst.