Abstract
The aim of this study was to evaluate the use of serum type II collagen cleavage epitope and serum hyaluronic acid as biomarkers for treatment monitoring in osteoarthritic dogs. For this purpose, a treatment model based on mesenchymal stem cells derived from adipose tissue combined with plasma rich in growth factors was used. This clinical study included 10 dogs with hip osteoarthritis. Both analytes were measured in serum at baseline, just before applying the treatment, and 1, 3, and 6 months after treatment. These results were compared with those obtained from force plate analysis using the same animals during the same study period. Levels of type II collagen cleavage epitope decreased and those of hyaluronic acid increased with clinical improvement objectively verified via force plate analysis, suggesting these two biomarkers could be effective as indicators of clinical development of joint disease in dogs.
Publication types
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Clinical Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Biomarkers / blood
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Biomechanical Phenomena
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Collagen Type II / blood*
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Dogs
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Epitopes / blood*
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Follow-Up Studies
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Hyaluronic Acid / blood*
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Osteoarthritis, Hip / blood*
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Osteoarthritis, Hip / physiopathology
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Osteoarthritis, Hip / therapy
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Osteoarthritis, Hip / veterinary*
Substances
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Biomarkers
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Collagen Type II
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Epitopes
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Hyaluronic Acid
Grants and funding
The Fundación Garcia Cugat, which supported this research study, received funds from the Ministerio de Sanidad, politica e Igualdad of Spain (grant N° EC11-0046). The Fundación Garcia Cugat is a non-profit institution that supports biomedical research. This institution does not promote or commercialize therapies or techniques of any kind. Artroscopia GC is a company and one of the contributors to the Fundación. The authors affiliated with the Fundación and Artroscopia GC collaborated as coauthors in the study design, data collection and analysis, decision to publish, and preparation of the manuscript.