A review of 104 children affected with respiratory tract allergies and or rhinoconjunctivitis in hyposensitizing therapy against gramineae pollens or moulds or house dust or Mix dermatophagoides is presented. Clinical evaluations were carried out in order to evaluate the clinical improvement after 1 year and after 4 years therapy (TIS). The best results were detected after 4 years obviously and in some allergic diseases more improvement were found from the authors. The most important results were obtained in bronchial asthma; the worse benefits were detected in allergic conjunctivitis.