Shift Work: A Risk Factor for Central Serous Chorioretinopathy

Elodie Bousquet; Myriam Dhundass; Mathieu Lehmann; Pierre-Raphaël Rothschild; Virginie Bayon; Damien Leger; Ciara Bergin; Ali Dirani; Talal Beydoun; Francine Behar-Cohen

doi:10.1016/j.ajo.2016.02.012

Shift Work: A Risk Factor for Central Serous Chorioretinopathy

Am J Ophthalmol. 2016 May:165:23-8. doi: 10.1016/j.ajo.2016.02.012. Epub 2016 Feb 22.

Authors

Affiliations

¹ Department of Ophthalmology, Hôtel-Dieu of Paris, Assistance Publique-Hôpitaux de Paris, AP-HP, Paris, France, Université Sorbonne Paris Cité, Paris, France; Inserm U1138, Team 17, Université Sorbonne Paris Cité, Université Pierre et Marie Curie, Centre de Recherche des Cordeliers, Paris, France. Electronic address: [email protected].
² Department of Ophthalmology, Hôtel-Dieu of Paris, Assistance Publique-Hôpitaux de Paris, AP-HP, Paris, France, Université Sorbonne Paris Cité, Paris, France.
³ Department of Ophthalmology, Hôtel-Dieu of Paris, Assistance Publique-Hôpitaux de Paris, AP-HP, Paris, France, Université Sorbonne Paris Cité, Paris, France; Inserm U1138, Team 17, Université Sorbonne Paris Cité, Université Pierre et Marie Curie, Centre de Recherche des Cordeliers, Paris, France.
⁴ Sleep and Vigilance Center, Hôtel-Dieu of Paris, Assistance Publique-Hôpitaux de Paris, AP-HP, Paris, France, Université Sorbonne Paris Cité, Paris, France.
⁵ Department of Ophthalmology University of Lausanne, Jules Gonin Ophthalmic Hospital, Fondation Asile des Aveugles, Lausanne, Switzerland.
⁶ Inserm U1138, Team 17, Université Sorbonne Paris Cité, Université Pierre et Marie Curie, Centre de Recherche des Cordeliers, Paris, France; Department of Ophthalmology University of Lausanne, Jules Gonin Ophthalmic Hospital, Fondation Asile des Aveugles, Lausanne, Switzerland.

PMID: 26915576
DOI: 10.1016/j.ajo.2016.02.012

Abstract

Purpose: To investigate if shift work or sleep disturbances are risk factors for central serous chorioretinopathy (CSCR).

Design: Prospective case-control study.

Methods: Forty patients with active CSCR and 40 controls (age- and sex-matched) were prospectively recruited from the Ophthalmology Department of Hôtel Dieu Hospital, Paris, between November 2013 and December 2014. All patients were asked to complete a questionnaire addressing previously described risk factors and working hours, as well as the Insomnia Severity Index (ISI), a validated instrument for assessing sleep disturbances.

Results: The mean age of the CSCR group was 44 ± 9 years, whereas the mean age of the control group was 43 ± 10 years. By use of multivariate analysis, shift work (odds ratio [OR] [95% confidence interval]: 5 [1.2-20.4]; P = .02), steroid use (OR: 5.5 [1.1-26.2]; P = .03), and recent psychological stress (OR: 15.3 [4.1-54.5]; P < .001) were found to be independently associated with CSCR.

Conclusion: The outcomes of this study suggest that shift work is an independent risk factor of CSCR. Further studies are required to confirm these results and to examine if work reconversion would be beneficial in the treatment of patients with chronic/recurrent CSCR.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Case-Control Studies
Central Serous Chorioretinopathy / diagnosis
Central Serous Chorioretinopathy / epidemiology*
Female
Humans
Male
Middle Aged
Odds Ratio
Prospective Studies
Risk Factors
Sleep Disorders, Circadian Rhythm / diagnosis
Sleep Disorders, Circadian Rhythm / epidemiology*
Stress, Psychological / diagnosis
Stress, Psychological / epidemiology*
Surveys and Questionnaires
Work Schedule Tolerance*
Young Adult