Abstract
The synthesis of analogues of the potent N-acetylhexosaminidase inhibitor, PUGNAc, are described. These compounds were assayed against a set of biologically important N-acetyl-d-glucosaminidases and were found to vary in both potency and selectivity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Dose-Response Relationship, Drug
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Humans
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Molecular Conformation
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Phenylcarbamates / chemical synthesis
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Phenylcarbamates / chemistry
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Phenylcarbamates / pharmacology*
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Structure-Activity Relationship
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beta-N-Acetylhexosaminidases / antagonists & inhibitors*
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beta-N-Acetylhexosaminidases / metabolism
Substances
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Enzyme Inhibitors
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Phenylcarbamates
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beta-N-Acetylhexosaminidases