Abstract
In recent years, several near-infrared light absorbing inorganic nanomaterials have been developed for photothermal therapy. However, their biological fate after injection limits their clinical utilization. In this work, we developed a novel polymeric near-infrared light absorbing material based on a biocompatible thermoresponsive nanogel that is semi-interpenetrated with polyaniline, a conjugated polymer with strong near-infrared absorbance. This polymeric nanocomposite generates heat after being irradiated by NIR light, thereby inducing a local hyperthermia that is used for photothermal cancer therapy in vitro and in vivo.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acrylic Resins / chemistry
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Aniline Compounds / chemistry
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Animals
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Biocompatible Materials / chemistry
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Cell Line
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Cell Line, Tumor
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Cross-Linking Reagents / chemistry
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Female
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Gels / chemistry*
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Humans
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Hyperthermia, Induced / methods
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Infrared Rays
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Light
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Mice
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Mice, Nude
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Microscopy, Electron, Transmission
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Nanogels
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Nanoparticles / chemistry*
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Nanotechnology / methods
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Neoplasms / pathology
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Neoplasms / therapy*
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Phototherapy / methods*
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Polyethylene Glycols / chemistry*
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Polyethyleneimine / chemistry*
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Polymers / chemistry
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Scattering, Radiation
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Spectroscopy, Near-Infrared*
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Temperature
Substances
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Acrylic Resins
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Aniline Compounds
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Biocompatible Materials
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Cross-Linking Reagents
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Gels
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Nanogels
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Polymers
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polyaniline
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polyethylene glycol polyethyleneimine nanogel
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poly-N-isopropylacrylamide
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Polyethylene Glycols
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Polyethyleneimine