Abstract
Four new quinonoid naphthopyranones, ophioparmin (1), 4-methoxyhaemoventosins (2a and 2b), and 4-hydroxyhaemoventosin (3), together with anhydrofusarubin lactone (4) and haemoventosin (5) were isolated from the fruiting bodies of Ophioparma ventosa, a crustose lichen. Their structures were determined by spectroscopic analyses, and the absolute configurations of 1 and 2 were elucidated through experimental and calculated electronic circular dichroism analyses. Compounds 1, 2, and 5 exhibited moderate to strong antioxidant activities. The main pigment haemoventosin exhibited significant cytotoxicity toward a panel of nine cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Biphenyl Compounds / pharmacology
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Circular Dichroism
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Drug Screening Assays, Antitumor
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Fruiting Bodies, Fungal / chemistry
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Humans
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Inhibitory Concentration 50
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Lichens / chemistry*
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Molecular Structure
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Naphthoquinones / chemistry
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Naphthoquinones / isolation & purification*
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Naphthoquinones / pharmacology
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Nuclear Magnetic Resonance, Biomolecular
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Picrates / pharmacology
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Pyrans / chemistry
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Pyrans / isolation & purification*
Substances
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Antineoplastic Agents
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Biphenyl Compounds
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Naphthoquinones
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Picrates
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Pyrans
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ophioparmin
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1,1-diphenyl-2-picrylhydrazyl