Abstract
A mathematical model was defined to estimate the degree of in vivo activity against Plasmodium falciparum sporozoites expressed by volunteers vaccinated with a synthetic peptide comprising the immunodominant epitope of the circumsporozoite protein. Relative to the course of infection in non-immunized controls, infections in vaccinated volunteers corresponded to the neutralization or delay of development of greater than 99% of challenge sporozoites.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Humans
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Malaria / prevention & control*
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Models, Theoretical
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Oligopeptides / administration & dosage*
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Plasmodium falciparum / growth & development*
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Plasmodium falciparum / immunology
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Vaccination
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Vaccines, Synthetic / therapeutic use
Substances
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Oligopeptides
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Vaccines, Synthetic
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(asparaginyl-alanyl-asparaginyl-proline)3