Abstract
Insulin dependent diabetes is an organ specific immunologic disease caused by pancreatic B cell destruction, mediated by T lymphocytes Present knowledge about insulin dependent diabetes immunogenetics and their relationship with the HLA system is reviewed, highlighting the polymorphism of the D area of that system and its connectors with diabetes. Possible therapeutic interventions in the autoimmune destructive process are discussed.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Autoimmunity
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Diabetes Mellitus, Type 1* / complications
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Diabetes Mellitus, Type 1* / etiology
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Diabetes Mellitus, Type 1* / genetics
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Diabetes Mellitus, Type 1* / immunology
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Diabetic Angiopathies / complications*
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Genetic Predisposition to Disease
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HLA-D Antigens / genetics*
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Humans
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Major Histocompatibility Complex / immunology