Abstract
Photodynamic therapy for therapy-resistant cancers will greatly benefit from targeted delivery of tumor photosensitizing agents. In this study, a strategy for the site-specific conjugation of single domain antibodies onto liposomes containing the photosensitizer zinc phthalocyanine was developed and tested.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Line, Tumor
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Drug Carriers
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Humans
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Indoles / chemistry
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Isoindoles
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Kinetics
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Liposomes / chemistry*
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Mice
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Nanomedicine / methods
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Organometallic Compounds / chemistry
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Oxygen / chemistry
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Photochemotherapy / methods*
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Photosensitizing Agents / administration & dosage*
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Single-Domain Antibodies / chemistry*
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Zinc / chemistry
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Zinc Compounds
Substances
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Drug Carriers
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Indoles
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Isoindoles
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Liposomes
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Organometallic Compounds
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Photosensitizing Agents
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Single-Domain Antibodies
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Zinc Compounds
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Zn(II)-phthalocyanine
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Zinc
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Oxygen