The Application of Genetic Risk Scores in Age-Related Macular Degeneration: A Review

Jessica N Cooke Bailey; Joshua D Hoffman; Rebecca J Sardell; William K Scott; Margaret A Pericak-Vance; Jonathan L Haines

doi:10.3390/jcm5030031

The Application of Genetic Risk Scores in Age-Related Macular Degeneration: A Review

J Clin Med. 2016 Mar 4;5(3):31. doi: 10.3390/jcm5030031.

Authors

Jessica N Cooke Bailey^{1

2}, Joshua D Hoffman³, Rebecca J Sardell⁴, William K Scott⁵, Margaret A Pericak-Vance⁶, Jonathan L Haines^{7

8}

Affiliations

¹ Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA. [email protected].
² Institute for Computational Biology, Case Western Reserve University, Cleveland, OH 44106, USA. [email protected].
³ Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94158, USA. [email protected].
⁴ John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. [email protected].
⁵ John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. [email protected].
⁶ John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. [email protected].
⁷ Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA. [email protected].
⁸ Institute for Computational Biology, Case Western Reserve University, Cleveland, OH 44106, USA. [email protected].

Abstract

Age-related macular degeneration (AMD), a highly prevalent and impactful disease of aging, is inarguably influenced by complex interactions between genetic and environmental factors. Various risk scores have been tested that assess measurable genetic and environmental contributions to disease. We herein summarize and review the ability and utility of these numerous models for prediction of AMD and suggest additional risk factors to be incorporated into clinically useful predictive models of AMD.

Keywords: age-related macular degeneration (AMD); genetics; risk score.

Publication types

Review

Abstract

Publication types

Grants and funding