Toward a Molecular Definition of Leucine-Dependent mTORC1 Activation

Robert T Abraham

doi:10.1016/j.cmet.2016.02.012

Toward a Molecular Definition of Leucine-Dependent mTORC1 Activation

Cell Metab. 2016 Mar 8;23(3):397-8. doi: 10.1016/j.cmet.2016.02.012.

Author

Robert T Abraham¹

Affiliation

¹ Oncology-Rinat R&D Group, Pfizer Worldwide Research & Development, 10646 Science Center Drive/CB4, San Diego, CA 92121, USA. Electronic address: [email protected].

PMID: 26959180
DOI: 10.1016/j.cmet.2016.02.012

Abstract

The mechanistic target of rapamycin complex 1 (mTORC1) coordinates nutrient availability with cell growth. Recent reports by Sabatini and coworkers (Saxton et al., 2016; Wolfson et al., 2016) characterize a cytoplasmic amino acid receptor that couples the binding of leucine to the activation of mTORC1.