A Drug-Free Zone--Lymph Nodes as a Safe Haven for HIV

Cell Host Microbe. 2016 Mar 9;19(3):275-6. doi: 10.1016/j.chom.2016.02.018.

Abstract

Understanding where and how the HIV latent reservoir persists is essential for developing rational HIV cure strategies. In a recent paper in Nature, Lorenzo-Redondo et al. (2016) demonstrate that HIV persists and actively evolves within lymph nodes due to low antiretroviral drug penetration, revealing the need to target these drug-privileged sites.

Publication types

  • Comment

MeSH terms

  • Carrier State / drug therapy*
  • Carrier State / virology*
  • HIV Infections / drug therapy*
  • HIV Infections / virology*
  • HIV-1 / growth & development*
  • Humans
  • Viral Load*
  • Virus Replication*