Adenosine and Preexcitation Variants: Reappraisal of Electrocardiographic Changes

Ann Noninvasive Electrocardiol. 2016 Jul;21(4):420-4. doi: 10.1111/anec.12348. Epub 2016 Mar 10.

Abstract

Intravenous adenosine is a short-acting blocker of the atrioventricular node that has been used to unmask subtle or latent preexcitation, and also to enable catheter ablation in selected patients with absent or intermittent preexcitation. Depending on the accessory pathway characteristics, intravenous adenosine may produce specific electrocardiographic changes highly suggestive of the preexcitation variant. Herein, we view different ECG responses to this pharmacological test in various preexcitation patterns that were confirmed by electrophysiological studies. Careful analysis of electrocardiographic changes during adenosine test, with emphasis on P-delta interval, preexcitation degree, and atrioventricular block, can be helpful to diagnose the preexcitation variant/pattern.

Keywords: accessory pathway; adenosine; preexcitation variants.

Publication types

  • Case Reports

MeSH terms

  • Adenosine / therapeutic use*
  • Adolescent
  • Adult
  • Anti-Arrhythmia Agents / therapeutic use*
  • Catheter Ablation
  • Electrocardiography / methods*
  • Exercise Test
  • Female
  • Humans
  • Male
  • Pre-Excitation Syndromes / drug therapy*
  • Pre-Excitation Syndromes / physiopathology*
  • Wolff-Parkinson-White Syndrome / drug therapy*
  • Wolff-Parkinson-White Syndrome / physiopathology*
  • Wolff-Parkinson-White Syndrome / surgery

Substances

  • Anti-Arrhythmia Agents
  • Adenosine