Managing patients at genetic risk of breast cancer

Holly J Pederson; Shilpa A Padia; Maureen May; Stephen Grobmyer

doi:10.3949/ccjm.83a.14057

Managing patients at genetic risk of breast cancer

Cleve Clin J Med. 2016 Mar;83(3):199-206. doi: 10.3949/ccjm.83a.14057.

Authors

Holly J Pederson^{1

2

3

4}, Shilpa A Padia⁵, Maureen May⁶, Stephen Grobmyer^{7

8

9}

Affiliations

¹ Director, Medical Breast Services, Department of Breast Services, Cleveland Clinic, Cleveland, OH, USA. E-mail: [email protected].
² Department of General Surgery, Cleveland Clinic, Cleveland, OH, USA.
³ Clinical Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
⁴ Case Comprehensive Cancer Center representative to NCCN Breast Cancer Risk Reduction Committee.
⁵ Mount Carmel Medical Group, Columbus, OH, USA.
⁶ Allegheny Health Network, Pittsburgh, PA, USA.
⁷ Director, Department of Breast Services, Cleveland Clinic, Cleveland, OH, USA.
⁸ Director, Surgical Oncology, Department of General Surgery, Cleveland Clinic, Cleveland, OH, USA.
⁹ Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.

PMID: 26974991
DOI: 10.3949/ccjm.83a.14057

Abstract

Hereditary syndromes that increase the risk of breast cancer are not common, but it is critical to recognize and manage them appropriately. This paper reviews the management of patients with the most common hereditary breast cancer syndromes, ie, hereditary breast and ovarian cancer syndrome, hereditary diffuse gastric cancer, Cowden syndrome (PTEN hamartoma tumor syndrome), Peutz-Jeghers syndrome, and Li-Fraumeni syndrome.

Publication types

Review

MeSH terms

Breast Neoplasms* / epidemiology
Breast Neoplasms* / genetics
Breast Neoplasms* / therapy
Combined Modality Therapy
Disease Management*
Female
Genetic Predisposition to Disease*
Genetic Testing / methods*
Global Health
Humans
Incidence
Risk Assessment*

Supplementary concepts

Breast Cancer, Familial