Complete Genome Sequence of emm4 Streptococcus pyogenes MEW427, a Throat Isolate from a Child Meeting Clinical Criteria for Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus (PANDAS)

Kristin M Jacob; Theodore Spilker; John J LiPuma; Suzanne R Dawid; Michael E Watson Jr

doi:10.1128/genomeA.00127-16

Complete Genome Sequence of emm4 Streptococcus pyogenes MEW427, a Throat Isolate from a Child Meeting Clinical Criteria for Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus (PANDAS)

Genome Announc. 2016 Mar 17;4(2):e00127-16. doi: 10.1128/genomeA.00127-16.

Authors

Kristin M Jacob¹, Theodore Spilker¹, John J LiPuma¹, Suzanne R Dawid², Michael E Watson Jr³

Affiliations

¹ Division of Pediatric Infectious Diseases, Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan, USA.
² Division of Pediatric Infectious Diseases, Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan, USA Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
³ Division of Pediatric Infectious Diseases, Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan, USA [email protected].

Abstract

We report the complete genome assembly of the Streptococcus pyogenes type emm4 strain MEW427 (also referred to as strain UM001 in the Pediatric Acute-Onset Neuropsychiatric Syndrome [PANS] Research Consortium), a throat isolate from a child with acute-onset neuropsychiatric symptoms meeting clinical criteria for PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcus). The genome length is 1,814,455 bp with 38.51% G+C%.

Grants and funding

K12 HD028820/HD/NICHD NIH HHS/United States