Genetically humanized pigs exclusively expressing human insulin are generated through custom endonuclease-mediated seamless engineering

J Mol Cell Biol. 2016 Apr;8(2):174-7. doi: 10.1093/jmcb/mjw008. Epub 2016 Mar 18.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Genetically Modified / genetics*
  • CRISPR-Associated Proteins / metabolism*
  • Female
  • Gene Editing / methods*
  • Humans
  • Insulin, Regular, Human / biosynthesis
  • Insulin, Regular, Human / genetics*
  • Insulin, Regular, Human / metabolism
  • Male
  • Swine / genetics*
  • Swine, Miniature / genetics
  • Transcription Activator-Like Effector Nucleases / metabolism*

Substances

  • CRISPR-Associated Proteins
  • Insulin, Regular, Human
  • Transcription Activator-Like Effector Nucleases