Abstract
Two thiosemicarbazide derivatives 1 and 2, three 2-amino-1,3,4-thiadiazole derivatives 3-5, and three N1- substituted-4-methyl-1,2,4-triazole-5-thione derivatives 6-8 were synthesized and evaluated for their central nervous system effects using rodent behavioral models. With the exception of 6, all compounds were devoid of neurotoxicity and they did not affect the body temperature of mice. New lead structures 1-4 with potential analgesic activity were identified.
MeSH terms
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Analgesics / chemical synthesis
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Analgesics / chemistry
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Analgesics / pharmacology
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Analgesics / toxicity
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Animals
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Anxiety / drug therapy
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Body Temperature / drug effects
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Central Nervous System Agents / chemical synthesis
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Central Nervous System Agents / chemistry
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Central Nervous System Agents / pharmacology*
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Central Nervous System Agents / toxicity
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Depression / drug therapy
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Dose-Response Relationship, Drug
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Drug Evaluation, Preclinical
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Female
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Mice
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Molecular Structure
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Motor Activity / drug effects
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Nociceptive Pain / drug therapy
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Seizures / drug therapy
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Semicarbazides / chemistry
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Semicarbazides / pharmacology*
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Semicarbazides / toxicity
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Sleep / drug effects
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Thiadiazoles / chemical synthesis
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Thiadiazoles / chemistry
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Thiadiazoles / pharmacology*
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Thiadiazoles / toxicity
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Triazoles / chemical synthesis
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Triazoles / chemistry
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Triazoles / pharmacology*
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Triazoles / toxicity
Substances
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Analgesics
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Central Nervous System Agents
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Semicarbazides
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Thiadiazoles
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Triazoles
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thiosemicarbazide