Abstract
Salinomycin is a promising anti-cancer agent which selectively targets cancer stem cells. To improve its potency and selectivity, an analog library of salinomycin was generated by site-specific modification and CuAAc derivatization. Through a cytotoxicity analysis of the library, a fluorinated analog with high potency, selectivity, and (19)F MRI sensitivity was discovered as a novel theranostic agent.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology*
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Apoptosis / drug effects
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Cell Line, Tumor
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Cell Survival / drug effects
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Crystallography, X-Ray
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Halogenation
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Humans
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Magnetic Resonance Imaging*
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Mice
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Models, Molecular
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Neoplasms / diagnostic imaging*
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Neoplasms / drug therapy*
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Pyrans / chemistry*
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Pyrans / pharmacology*
Substances
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Antineoplastic Agents
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Pyrans
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salinomycin