Metal-Free Tandem Oxidative Coupling of Primary Alcohols with Azoles for the Synthesis of Hemiaminal Ethers

Jinwei Sun; Yu Zhang; Sankaran Mathan; Yi Wang; Yi Pan

doi:10.1021/acs.joc.5b02516

Metal-Free Tandem Oxidative Coupling of Primary Alcohols with Azoles for the Synthesis of Hemiaminal Ethers

J Org Chem. 2016 Apr 15;81(8):3380-5. doi: 10.1021/acs.joc.5b02516. Epub 2016 Mar 25.

Authors

Jinwei Sun¹, Yu Zhang¹, Sankaran Mathan¹, Yi Wang¹, Yi Pan^{1

2

3}

Affiliations

¹ School of Chemistry & Chemical Engineering, Nanjing University , Nanjing, 210093, China.
² State of Key Laboratory of Coordination, Nanjing University , Nanjing, 210093, China.
³ Collaborative Innovation Center of Advanced Microstructures, Nanjing University , Nanjing, 210093, China.

PMID: 27000768
DOI: 10.1021/acs.joc.5b02516

Abstract

A novel metal-free tandem oxidative coupling process for the synthesis of hemiaminal ethers has been developed. This protocol could be applied for the C-N bond formation of electron-deficient trizoles, tetrazoles, carbazoles and indazoles with primary alcohols.

Publication types

Research Support, Non-U.S. Gov't