Disorder-specific versus transdiagnostic and clinician-guided versus self-guided internet-delivered treatment for panic disorder and comorbid disorders: A randomized controlled trial

V J Fogliati; B F Dear; L G Staples; M D Terides; J Sheehan; L Johnston; R Kayrouz; R Dear; P M McEvoy; N Titov

doi:10.1016/j.janxdis.2016.03.005

Disorder-specific versus transdiagnostic and clinician-guided versus self-guided internet-delivered treatment for panic disorder and comorbid disorders: A randomized controlled trial

J Anxiety Disord. 2016 Apr:39:88-102. doi: 10.1016/j.janxdis.2016.03.005. Epub 2016 Mar 15.

Authors

V J Fogliati¹, B F Dear², L G Staples¹, M D Terides¹, J Sheehan¹, L Johnston¹, R Kayrouz¹, R Dear¹, P M McEvoy³, N Titov¹

Affiliations

¹ eCentreClinic, Department of Psychology, Macquarie University, Sydney, Australia.
² eCentreClinic, Department of Psychology, Macquarie University, Sydney, Australia. Electronic address: [email protected].
³ School of Psychology and Speech Pathology, Curtin University, Australia.

PMID: 27003376
DOI: 10.1016/j.janxdis.2016.03.005

Abstract

Transdiagnostic cognitive behaviour therapy (TD-CBT) aims to target the symptoms of multiple disorders whereas disorder-specific CBT (DS-CBT) targets the symptoms of principal disorders. This study compared the relative benefits of internet-delivered TD-CBT and DS-CBT when provided in clinician-guided (CG-CBT) and self-guided (SG-CBT) formats for people with a principal diagnosis of Panic Disorder (PD). Participants (n=145) were randomly allocated to receive TD-CBT or DS-CBT and CG-CBT or SG-CBT. Large reductions in symptoms of PD (Cohen's d ≥ 0.71; avg. reduction ≥ 36%) and moderate-to-large reductions in symptoms of comorbid depression (Cohen's d ≥ 0.71; avg. reduction ≥ 33%), generalised anxiety disorder (Cohen's d ≥ 0.91; avg. reduction ≥ 34%) and social anxiety disorder (Cohen's d ≥ 0.50; avg. reduction ≥ 15%) were found over the 24-month follow-up period. Highlighting their efficacy and acceptability, no marked and consistent differences were observed between TD-CBT and DS-CBT or CG-CBT and DS-CBT.

Keywords: 24-month follow-up; Anxiety disorders; Depression, treatment; Disorder-specific; Internet; Panic disorder; Randomized controlled trial; Self-guided; Therapist-guided; Transdiagnostic.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Anxiety Disorders / epidemiology*
Anxiety Disorders / therapy*
Cognitive Behavioral Therapy
Comorbidity
Depressive Disorder / therapy
Female
Follow-Up Studies
Humans
Internet*
Male
Panic Disorder / epidemiology*
Panic Disorder / therapy*
Phobia, Social / therapy
Stress Disorders, Traumatic, Acute / therapy
Therapy, Computer-Assisted*
Treatment Outcome