A review on pregnancy after intestinal transplantation

J Matern Fetal Neonatal Med. 2017 Jan;30(2):205-212. doi: 10.3109/14767058.2016.1168801. Epub 2016 Apr 14.

Abstract

The largest experience of pregnancy after solid organ transplantation is recorded in renal and liver recipients. Intestinal/multivisceral transplantation has shown steady improvements in graft and patient survival over the past 20 years and is rapidly becoming more established: the first pregnancy after this procedure was described 10 years ago, and so far eight cases of pregnancies with 100% successful live births have been reported worldwide. Specifically to this procedure, there are 2 factors to be considered in case of pregnancy: absorptive function of transplanted bowel and higher need of immune-suppressants. Close monitoring of renal function and of the graft by endoscopies and biopsies can be considered during the pregnancy to prevent episodes of rejection or enteritis, preserving the fetus by temporary malnutrition. As more intestinal transplant patients are surviving and regaining reproductive function, it is important to report this option to female recipients and to their health-care professionals.

Keywords: Intestinal transplantation; immune-suppression; pregnancy.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Female
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Infant, Newborn
  • Intestines / transplantation*
  • Organ Transplantation / adverse effects*
  • Pregnancy
  • Pregnancy Complications / drug therapy
  • Pregnancy Outcome*
  • Primary Graft Dysfunction / complications
  • Young Adult

Substances

  • Immunosuppressive Agents