Association of the chromosome 11p13.5 variant and atopic dermatitis with a family history of atopy in the Chinese Han population

Asian Pac J Allergy Immunol. 2016 Jun;34(2):109-14. doi: 10.12932/AP0596.34.2.2016.

Abstract

Background: Recent genome-wide association studies (GWAS) and a meta-analysis of GWAS for atopic dermatitis (AD) have identified some AD genetic loci in European and Japanese populations.

Objective: To investigate whether some novel susceptibility loci are associated with AD in the Chinese Han population.

Methods: We first selected eight novel susceptibility loci to replicate in 2,205 AD patients and 2,116 healthy controls using the Sequenom platform. Data were analyzed with PLINK 1.07 software.

Results: We found that rs12634229 (3q13.2), rs7927894 (11p13.5) and rs878860 (11p15.4) showed a slight association with AD (P = 0.012, P = 0.033, P = 0.020, respectively); rs6780220 (3p21.33) was preferentially related to AD with keratosis pilaris, but did not reach the threshold of significance after correction. The frequency of rs7927894 allele T was significantly different between AD patients with a positive and negative family history of atopy.

Conclusion: The loci rs7927894 (11p13.5) are related to AD with a positive family history of atopy in Chinese Han population, providing novel insight into the genetic pathogenesis of AD.

MeSH terms

  • Adolescent
  • Adult
  • Asian People / genetics*
  • Case-Control Studies
  • Child
  • Child, Preschool
  • China / epidemiology
  • Chromosomes, Human, Pair 11*
  • Dermatitis, Atopic / diagnosis
  • Dermatitis, Atopic / ethnology
  • Dermatitis, Atopic / genetics*
  • Female
  • Gene Frequency
  • Genetic Association Studies
  • Genetic Loci
  • Genetic Predisposition to Disease
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Pedigree
  • Phenotype
  • Polymorphism, Single Nucleotide*
  • Risk Factors
  • Severity of Illness Index
  • Young Adult