The Molecular Harbingers of Early Mammalian Embryo Patterning

Jun Wu; Juan Carlos Izpisua Belmonte

doi:10.1016/j.cell.2016.03.005

The Molecular Harbingers of Early Mammalian Embryo Patterning

Cell. 2016 Mar 24;165(1):13-15. doi: 10.1016/j.cell.2016.03.005.

Authors

Jun Wu¹, Juan Carlos Izpisua Belmonte²

Affiliations

¹ Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
² Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: [email protected].

PMID: 27015301
DOI: 10.1016/j.cell.2016.03.005

Abstract

Random or not, the mechanisms at play during the first cell-fate determination in mammalian embryos have been debated for years. Studies by Goolam et al. and White et al. shed new light on the molecular mechanisms underlying the intrinsic biases that lead to non-random lineage segregation in early mammalian development.

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MeSH terms

Animals
Body Patterning
Cell Differentiation*
Cell Lineage
Embryo, Mammalian*