Prognostic value of funisitis and/or chorionic vasculitis compared to histologic chorioamnionitis in full-term infants

J Matern Fetal Neonatal Med. 2017 Jan;30(2):169-173. doi: 10.3109/14767058.2016.1165200. Epub 2016 Mar 29.

Abstract

Aim: To compare pathological findings in the placenta and cord with the prognosis of full-term infants in cases of neonatal infection and microbial analyses.

Methods: The pathological findings in the placenta and cord and microbial analyses of amniotic fluid and neonatal samples based on culture or polymerase chain reaction (PCR) were observed in 1208 full-term mother-infant pairs at our center. We also collected neonatal clinical infection data, such as the occurrence of septicemia and other infectious diseases.

Results: Neonatal infection and positive identification of microorganisms were more common in the funisitis and/or chorionic vasculitis group than in the histologic chorioamnionitis group.

Conclusion: Funisitis and/or chorionic vasculitis is a valuable pathological marker for assessing the comparison between intrauterine infection and neonatal inflammatory conditions in infants delivered at full-term.

Keywords: Full-term delivery; funisitis and/or chorionic vasculitis; histologic chorioamnionitis; intrauterine infection; microbial analysis; neonatal infection.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Amniotic Fluid / microbiology
  • Analysis of Variance
  • Chi-Square Distribution
  • Chorioamnionitis / diagnosis*
  • Chorion / pathology*
  • Female
  • Humans
  • Infant, Newborn
  • Placenta / pathology*
  • Pregnancy
  • Prognosis
  • Prospective Studies
  • ROC Curve
  • Umbilical Cord / pathology*
  • Vasculitis / diagnosis*