Indole Synthesis via Cobalt(III)-Catalyzed Oxidative Coupling of N-Arylureas and Internal Alkynes

Org Lett. 2016 Apr 15;18(8):1776-9. doi: 10.1021/acs.orglett.6b00494. Epub 2016 Mar 29.

Abstract

A mild Co(III)-catalyzed oxidative annulation of N-arylureas and internal alkynes has been developed. The use of less electrophilic ureas other than acetamides as directing groups is crucial for the reaction. A broad range of synthetically useful functional groups are compatible with this reaction, thus providing a new opportunity for the synthesis of diverse indoles.

Publication types

  • Research Support, Non-U.S. Gov't