The Effects of Two Novel Copper-Based Formulations on Helicobacter pylori

Ilaria M Saracino; Cristina Zaccaro; Giovanna Lo Re; Dino Vaira; John Holton

doi:10.3390/antibiotics2020265

The Effects of Two Novel Copper-Based Formulations on Helicobacter pylori

Antibiotics (Basel). 2013 May 21;2(2):265-73. doi: 10.3390/antibiotics2020265.

Authors

Ilaria M Saracino¹, Cristina Zaccaro², Giovanna Lo Re³, Dino Vaira⁴, John Holton⁵

Affiliations

¹ First Medical Clinic, University of Bologna, Bologna 40121, Italy. [email protected].
² First Medical Clinic, University of Bologna, Bologna 40121, Italy. [email protected].
³ First Medical Clinic, University of Bologna, Bologna 40121, Italy. [email protected].
⁴ First Medical Clinic, University of Bologna, Bologna 40121, Italy. [email protected].
⁵ Department of Health & Social Sciences, University of Middlesex, NW4 4Bt London, UK. [email protected].

Abstract

We investigated the effects of two novel copper-based inorganic formulations for their activity against 60 isolates of Helicobacter pylori (Hp). The two copper-based formulations were tested against three NCTC Helicobacter pylori isolates and 57 clinical strains isolated from the UK and Italy in time-kill assays. Both copper-based formulations were bio-cidal against all Helicobacter pylori strains tested reducing the viable count by 4-5 log within 2 h. These two copper-based anti-microbial agents deserve further study in relation to the treatment of H. pylori-related gastric disease.

Keywords: bactericidal; copper; helicobacter; novel formulation.