Switchable probes: pH-triggered and VEGFR2 targeted peptides screening through imprinting microarray

Yixia Qian; Weizhi Wang; Zihua Wang; Qiuju Han; Xiangqian Jia; Shu Yang; Zhiyuan Hu

doi:10.1039/c6cc01302c

Switchable probes: pH-triggered and VEGFR2 targeted peptides screening through imprinting microarray

Chem Commun (Camb). 2016 Apr 28;52(33):5690-3. doi: 10.1039/c6cc01302c.

Authors

Yixia Qian¹, Weizhi Wang², Zihua Wang², Qiuju Han³, Xiangqian Jia³, Shu Yang², Zhiyuan Hu²

Affiliations

¹ CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China. [email protected] [email protected] and University of Chinese Academy of Science, No. 19A Yuquan Road, Beijing 100049, China and Sino-Danish Center for Education and Research, Beijing, 100190, China.
² CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China. [email protected] [email protected].
³ CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China. [email protected] [email protected] and Pharmacy College, Liaoning Medical University, Jinzhou, Liaoning 121001, China.

PMID: 27035754
DOI: 10.1039/c6cc01302c

Abstract

One switchable affinity peptide, STP, is screened out from a high-throughput library by an integrated imprinting microarray. STP is pH triggered and also the ligand of the marker VEGFR2. Efficient cell recognition and penetration as well as an in vivo image could be "turned on" and accelerated only in the condition of VEGFR2 overexpression and a mild acidic environment.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Hydrogen-Ion Concentration*
Molecular Probes / chemistry*
Peptides / chemistry*
Vascular Endothelial Growth Factor Receptor-2 / chemistry*

Substances

Molecular Probes
Peptides
Vascular Endothelial Growth Factor Receptor-2