Development and function of tissue resident macrophages in mice

Katrin Kierdorf; Marco Prinz; Frederic Geissmann; Elisa Gomez Perdiguero

doi:10.1016/j.smim.2016.03.017

Development and function of tissue resident macrophages in mice

Semin Immunol. 2015 Dec;27(6):369-78. doi: 10.1016/j.smim.2016.03.017. Epub 2016 Mar 29.

Authors

Katrin Kierdorf¹, Marco Prinz², Frederic Geissmann³, Elisa Gomez Perdiguero⁴

Affiliations

¹ Centre for Molecular and Cellular Biology of Inflammation (CMCBI), King's College London, London, UK.
² Institute of Neuropathology, University Freiburg, Freiburg, Germany; BIOSS Centre for Biological Signaling Studies, University of Freiburg, Freiburg, Germany.
³ Centre for Molecular and Cellular Biology of Inflammation (CMCBI), King's College London, London, UK; Immunology Program, Memorial Sloan Kettering Cancer Center, NY, NY, USA.
⁴ Macrophages and Endothelial Cells group, Department of Developmental and Stem Cell Biology, CNRS UMR 3738, Institut Pasteur, Paris, France. Electronic address: [email protected].

Abstract

Macrophages are important for tissue development, homeostasis as well as immune response upon injury or infection. For a long time they were only seen as one uniform group of phagocytes with a common origin and similar functions. However, this view has been challenged in the last decade and revealed a complex diversity of tissue resident macrophages. Here, we want to present the current view on macrophage development and tissue specification and we will discuss differences as well as common patterns between heterogeneous macrophage subpopulations.

Keywords: Erythro-myeloid progenitor; Macrophage; Mononuclear phagocytes; Pulse labeling models; Tissue specification.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Macrophages / cytology*
Macrophages / immunology*
Mice
Models, Biological
Stem Cells / cytology
Stem Cells / immunology

Grants and funding

P30 CA008748/CA/NCI NIH HHS/United States