Longitudinal analysis of cytokine expression during neoadjuvant chemoradiotherapy and subsequent surgery in esophageal cancer patients

Dirk J Bosch; Da Wang; Maarten W N Nijsten; Véronique E M Mul; Geke A P Hospers; Johannes G M Burgerhof; Michel M R F Struys; John Th M Plukker

doi:10.1016/j.amjsurg.2015.12.021

Longitudinal analysis of cytokine expression during neoadjuvant chemoradiotherapy and subsequent surgery in esophageal cancer patients

Am J Surg. 2016 Jul;212(1):89-95. doi: 10.1016/j.amjsurg.2015.12.021. Epub 2016 Feb 27.

Authors

Dirk J Bosch¹, Da Wang¹, Maarten W N Nijsten², Véronique E M Mul³, Geke A P Hospers⁴, Johannes G M Burgerhof⁵, Michel M R F Struys⁶, John Th M Plukker⁷

Affiliations

¹ Department of Surgery/Surgical Oncology, University of Groningen, University Medical Center Groningen (UMCG), Hanzeplein 1, PO Box 30001, Groningen, 9700 RB, The Netherlands.
² Department of Critical Care, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The Netherlands.
³ Department of Radiation Oncology, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The Netherlands.
⁴ Department of Medical Oncology, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The Netherlands.
⁵ Department of Epidemiology, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The Netherlands.
⁶ Department of Anesthesiology, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The Netherlands.
⁷ Department of Surgery/Surgical Oncology, University of Groningen, University Medical Center Groningen (UMCG), Hanzeplein 1, PO Box 30001, Groningen, 9700 RB, The Netherlands. Electronic address: [email protected].

PMID: 27036621
DOI: 10.1016/j.amjsurg.2015.12.021

Abstract

Background: The purpose of this study was to provide more insight in the course of cytokine concentrations related to pathologic response (pR) and complications after neoadjuvant chemoradiotherapy (NCRT) and esophagectomy in esophageal cancer patients.

Methods: Patients treated with NCRT followed by transthoracic esophagectomy (n = 35) or transthoracic esophagectomy alone (n = 8) were included. Eight different cytokine concentrations were determined during NCRT, esophagectomy, and the first postoperative week.

Results: Platelet-activating factor before NCRT was associated with pR (P = .011) and remained elevated in patients with a better response. Concentrations of intestinal fatty acid-binding protein and angiopoietin 1 (Ang-1) were different between patients with and without NCRT. Decreased concentrations of Ang-1 on the third postoperative day were associated with postoperative complications (P = .046).

Conclusions: In this observational study, elevated platelet-activating factor concentrations before NCRT were associated with pR. NCRT is associated with decreased Ang-1 concentrations, whereas reduced Ang-1 concentrations were associated with postoperative complications.

Keywords: Cytokine; Esophagectomy; Neoadjuvant chemoradiotherapy.

Publication types

Comparative Study

MeSH terms

Adenocarcinoma / mortality
Adenocarcinoma / pathology
Adenocarcinoma / therapy
Aged
Biomarkers, Tumor / blood
Carcinoma, Squamous Cell / mortality
Carcinoma, Squamous Cell / pathology
Carcinoma, Squamous Cell / therapy
Chemoradiotherapy / adverse effects
Chemoradiotherapy / methods*
Cohort Studies
Combined Modality Therapy
Cytokines / blood*
Disease-Free Survival
Esophageal Neoplasms / mortality
Esophageal Neoplasms / pathology
Esophageal Neoplasms / therapy*
Esophagectomy / methods*
Female
Humans
Longitudinal Studies
Male
Middle Aged
Neoadjuvant Therapy / adverse effects
Neoadjuvant Therapy / methods*
Prognosis
Prospective Studies
Statistics, Nonparametric
Survival Analysis
Treatment Outcome

Substances

Biomarkers, Tumor
Cytokines